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🔢 We overlapped 4,724 genetic variants across 14 immune diseases with cis-regulatory elements that were accessible in CD4+ T cells ⚡️ Perturbing these elements with TAP-seq (tinyurl.com/TAPseq) revealed the genes they regulate. Best computational predictors? ENCODE-rE2G and eQTLs
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Targeted Perturb-seq enables genome-scale genetic screens in single cells - Nature Methods
Targeted sequencing of perturbation effects offers a sensitive approach to capture genes of interest in CRISPR-mediated screens, enabling genome-scale screens at higher scale and lower cost than whole...
www.nature.com
Annique Claringbould