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We lay out predictions and propose experiments. Short-lived models with tractable immunity (killifish, zebrafish, Drosophila) are a natural place to start. šŸ”— journals.plos.org/plosbiology/...
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journals.plos.org
Host-associated microbiomes are stable across most of the lifespan, but what drives late-life deterioration remains unclear. This Unsolved Mystery proposes interventions that restore immune surveillan...
Immune surveillance and microbial escape in the aging host: Why does the microbiome lose its balance?
Dario Riccardo Valenzano