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by @jimpick.com
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Delighted to share our latest collaborative research paper with my long term collaborators Nigel Greig and W. Douglas Figg showing Thalidomide-like monoterpenoid analogues, unlike classic IMiDs, lack cereblon binding and they have anti-angiogenesis actions. www.sciencedirect.com/science/arti...
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Immunomodulatory imide drugs (IMiDs) designed on the backbone of thalidomide are highly effective in the treatment of multiple myeloma (MM). However, …
www.sciencedirect.com
Monoterpenoid fluorophthalimide IMiDs that lack human cereblon binding: synthesis and anti-proliferative, anti-angiogenic and anti-inflammatory activities