Researcher, evolution of drug resistance, modeling, population genetics, coding, no longer at SF State University, instead at the U of Montpellier.
Mom, Dutch, now immigrant in France.
Pleuni Pennings
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And it is not just resistance to quinolones in E coli that stopped increasing. This graph shows resistance to a different drug (cefotaxime) in a different bacterium (K. pneumonia) in a different country (France) about 5 years later. It also shows an increase and a plateau.
Wow this is an amazing resource for those who are considering applying for PhD programs in ecology and evolution and related fields in the US.
Pleuni Pennings
I enjoyed watching Ronny Chieng's speech for one of the Harvard graduation events.
www.youtube.com/live/ORq_Hi5...
So it turns out that after these six years, there was almost no further increase.
One of the big surprises in the world of drug resistance: in many cases resistance levels stop increasing even when we don't change how we use the drugs.
In HIV the sequencing data are not old enough to show the initial increase, but plateaus exists here too. This graph shows NRTI resistance in sub-saharan Africa, which has been stable at just under 2% of new infections. Data from: hivdb.stanford.edu/project/surv...
Imagine you had six years of data and every year resistance levels go up ... What would you think will happen in the future?
(here showing data from quinolone resistance in E coli in Hungary from the supplement of this paper by @sonjalehtinen.bsky.social et al journals.plos.org/plospathogen...
