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Drosophilist, DIY enthusiast, group leader, senior fellow & Dementia Research Leader Fellow based in SITraN, Sheffield, UK. Working on #FTD, #ALS and #MND Find us here: sites.google.com/view/the-west-lab-sheffield
Ryan West








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and thanks to @alzheimerssoc.bsky.social and others for supporting this work
I'm looking forward to discussing our work at Tambourine’s ALS Breakthrough Research Fund investigators meeting this week. A pretty good view from my room
Somewhat depleted in numbers due to illnesses half the lab made it out for our annual, rather wet, lab winter walk
Moody skies over Sheffield from the office window this morning
taking a break from all the hills and letting the 5 yo loose down the monsal trail
Scott Allen and myself have an opportunity for a postdoc working on pyruvate metabolism in normoxia and hypoxia using a combination of C9orf72 patient-derived iNPC and Drosophila models. Based at SITraN (sheffield.ac.uk/sitran) jobsite.sheffield.ac.uk/job/Research...
We are pleased that our article on Ataxin-2 and the integrated stress response in C9orf72 ALS/FTD is finally published in full. A lot of hard work from members of the lab, including @comeflywithjo.bsky.social, and our collaborators link.springer.com/article/10.1...
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Check out our new #neuroscience @BiologyatYork banner to showcase our diverse, multidisciplinary, multi model, and so much fun research environment that you could be in by joining us as an under or postgrad york.ac.uk/study/undergra… or/and postgrad too!
9mo
1d
Mar 19, 2025
Frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) are fatal, early-onset neurodegenerative diseases. The most common genetic cause of FTD and ALS is a G4C2 hexanucleotide repeat ex...
Targeting the integrated stress response or Ataxin-2 alleviates neurodegeneration in PolyGR models of C9orf72 associated frontotemporal dementia and amyotrophic lateral sclerosis - Acta Neuropathologi...
link.springer.com
Ryan West
Ryan West
Ryan West
Ryan West
πŸš€ Hot off the press! Our team findings @livuni-ismib.bsky.social on brain ageing unveil a novel connection between oxidative stress, neuronal microtubules, and the cytoskeletal protein EB1 driving neuronal atrophy. πŸŽ‰ A huge thank you to the fantastic team! www.aginganddisease.org/EN/10.14336/...
Ryan West
Ryan West
Ryan West
Jan 17, 2025
Ines Hahn
Natalia Sanchez-Soriano