UPMC did not disclose which hospitals were affected by the layoffs or provide other specifics. Word about the layoffs first circulated on Pittsburgh social media platforms.
The health system operates more than 40 hospitals and another 800 clinical facilities across much of Pennsylvania.
UPMC laid off 200 workers and eliminated 300 vacant positions Tuesday. The health system said the cuts were part of a routine labor force realignment and affected non-clinical positions.