Interestingly mutations outside of this region can cause haploinsufficiency or gain-of-function effects with milder effects on synaptic output that result in less severe behavioral phenotypes in patients.
Drosophila community - Monday is the deadline for submitting a student nomination for the Elkins Memorial Lecture at the 2025 CSHL Neurobiology of Drosophila Meeting. It’s a great opportunity to support and recognize our graduate student colleagues in the field! Please spread the word!
Drosophila community friends - please help spread the word for nominations for the Elkins Memorial Lecture at the 2025 Cold Spring Harbor Lab Neurobiology of Drosophila Meeting. It’s a great opportunity to support and recognize our graduate student colleagues in the field!
Her findings reveal the most severe mutations are in the C2B Ca2+ binding pocket and act dominantly to poison the synaptic vesicle fusion machinery and block release sites.
Zhou Guan’s preprint from the lab on how mutations in Synaptotagmin 1 and 2 disrupt neurotransmitter release to cause human neurological diseases is available at BioRxiv.
www.biorxiv.org/content/10.6...