🚨 New paper! By combining protein language models, clustering, and DCA, we reveal how MSA subclusters drive AF2 predictions toward alternative conformations, and how statistics from the clustered sequences can inform deisgn of mutations that shift conformer populations.
Valerio Piomponi
Evolutionary constraints guide AlphaFold2 prediction of alternative conformations and inform rational mutation design [new]
AlphaFold2: Protein conf. via evolution. Coevolution stabilizes.
