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Clear evidence from Josh Shin in our lab that mTORC1 signaling and autophagy reciprocally influence the length of primary cilia. Question remains how do changes in length affect cilia signaling and function in the largely quiescent cells comprising our brains and bodies. www.cell.com/iscience/ful...
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Growth factor-independent mTORC1 signaling promotes primary cilia length via suppression of autophagy
Molecular physiology; Cell biology
www.cell.com
Brendan Manning