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But it turns out the ability to induce a strong immune response is separate from these effects and we have had a bunch of recent work showing that it is possible to simultaneously make mRNA vaccines more effective AND make them a much more tolerable experience for people: rdcu.be/fosUY
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Nature Materials - Lipid nanoparticles incorporating a crosslinked ionizable lipid are shown to promote efficient endosomal escape of antigen mRNA and glycolysis stimulation in dendritic cells, to...
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Crosslinked ionizable lipids reprogram dendritic cell metabolism for potent mRNA vaccination
Edward Nirenberg