//
sign in
Post
by @danabra.mov
PostEmbed
by @danabra.mov
Record
by @jimpick.com
Record
by @atsui.org
+ new component
Post
Congratulations Thi Nguyen, @konjikusicmia.bsky.social, Lorenzo del Castillo and Roshank Irannejad on this new paper! I'm proud of you all. Thank you, Dagmar Wachten, for editing. Everyone else, please send thoughts, comments, critiques and questions: plos.io/4v7vdnp
21h
Hedgehog signaling in vertebrates is transduced by the transmembrane protein Smoothened (SMO) on the primary cilium, but the underlying mechanisms remain unclear. This study shows that SMO and ciliary...
plos.io
Smoothened and ciliary GPCRs regulate ciliary protein kinase A activity involved in Hedgehog signal transduction
Jeremy Reiter
Vertebrate #Hedgehog signaling is transduced by transmembrane protein Smoothened (SMO) on the primary #cilium, but what is its mechanism? @reitergroup.bsky.social &co show that SMO & ciliary GPCRs regulate ciliary PKA activity to activate the Hedgehog pathway @plosbiology.org 🧪 plos.io/4v7vdnp
22h
PLOS Biology