Just published in Organic Letters! 📢
Our latest work presents a modular, metal-free route to arene-annulated azocines via a Lewis acid-catalyzed domino IEDDA/thermal ring-expansion. These eight-membered N-heterocycles show potential for medicinal chemistry and beyond.đź’Š
👉 doi.org/10.1021/acs....
A domino inverse electron-demand Diels–Alder reaction/thermal ring expansion sequence was developed to enable the one-step synthesis of arene-annulated eight-membered nitrogen heterocycles from readil...
