Molecular microbiologist at the University of St Andrews, Scotland. My scientific interests include: CRISPR, antiviral defence, cyclic nucleotide signalling, archaea, nucleases.
Malcolm White
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CapK is a bacterial DNA damage-activated kinase that phosphorylates transcriptional repressor CapS to control adjacently-encoded anti-phage immune pathway genes in response to a universal stress signal, DNA damage
@kevincorbett.bsky.social and colleagues
link.springer.com/article/10.1...
Our paper "Gene ancestries reveal diverse microbial associations during eukaryogenesis.” is finally out in Nature.
Eukaryogenesis was likely a gradual process shaped by multiple microbial partners and virus-mediated gene transfer, rather than a single binary symbiosis.
doi.org/10.1038/s415...
Oops, Minoan not Phoenician! Apologies to the Minoans.
Bacteria encode numerous stress-response pathways that protect their hosts against both internal and external threats. A key question is how these pathways are regulated, especially anti-phage immune ...
Mechanistic insights into activation of bacterial Retron-Eco8 immunity by phage protein SSB | Nature Communications https://www.nature.com/articles/s41467-026-74106-9
Synthetically designed anti-defense proteins overcome barriers to bacterial transformation and phage infection | Nature Communications https://www.nature.com/articles/s41467-026-74301-8
www.nature.com/articles/s41...
#phage#phagesky
DNA-intercalating antiphage molecules trigger abortive infection through mutual destruction and synergize with bacterial immunity | PNAS https://www.pnas.org/doi/abs/10.1073/pnas.2602073123?af=R
In Heraklion, for @biochemsoc.bsky.social Harden Conference, Machines on Genes #BiochemEvent. Amazed by the Phoenician ceramics (nearly 4000 years old) in the archaeological museum - puts our pot shards into perspective!
Machines on Genes running smoothly in Heraklion #BiochemEvent @biochemsoc.bsky.social
Cheap and easy method for nanopore sequencing phage DNA directly from plaques.
Proud of lab members Brenna and Patrick for doing this work *with absolutely no help from me* !!
www.nature.com/articles/s41...
The EMBO Journal
Toni Gabaldón
Malcolm White
Scientific Reports - Same-day tagmentation PCR-based whole genome sequencing of bacteriophage genomes from a single plaque without DNA extraction
