This project started with confusion 🤔 www.nature.com/articles/s41...
Loss of LUBAC or OTULIN causes severe inflammatory disease. But patients also show clear metabolic defects.
Neither LUBAC nor OTULIN had been linked to metabolic regulation.
So where do these metabolic manifestations come from?
Rune Busk Damgaard
🧐 What if metabolic defects are not just a consequence of inflammatory disease - but actively contribute to it?
Inflammation and metabolism are deeply intertwined, but the molecular links remain unclear.
Our new paper in Cell Death & Differentiation uncovers one. 🧵👇
nature.com/articles/s41...
