Computational Cryo-EM/ET at Genentech
Love people, the outdoors and building stuff
Complexity is the enemy
All opinions my own
Alister Burt
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An elemental #birddivination from the elemental swan. As always, find it as a solo print and part of the deck of 100, along with the story and process behind them, at almanacofbirds.org
@mgflast.bsky.social knows wassup 🙏
Super cool cryo-ET work from my colleague Xiaohan resolving a ton of ribosome assembly intermediates in the nuclei of human cells!
Maria Popova
Alister Burt
The feedback from participants at the #SerialEM Community Meeting 2026 in April — and the future of this format — have been central topics in our recent discussions.
(Photo by Daniel Bollschweiler)
@mgflast.bsky.social showing us how to do cellular structural biology on easymode thanks to his collection of pretrained nets 😎
Particularly cool: he demonstrates custom tomo picking workflows e.g. yTuRC at the minus end of MTs, restricting picks to specific cellular compartments
Check it out!
Saw this right after being super impressed by something @przemekdut.bsky.social vibe coded 😂😂😂
“the best way to work with cryoET data is to engage with it directly, […] build familiarity with what is actually there. As tempting as it sometimes is to lean in to automation entirely, we cannot do visual proteomics by relying blindly on automation.”
mgflast.github.io/easymode/use...
“We are a yes-before-no group — not because every idea is good, but because the cost of quietly killing a good one is much higher than the cost of exploring a bad one for a day.”
Great read! I loved:
“Curiosity is a stance you choose every morning. When a colleague pitches an idea, our default is “interesting — tell me more,” not “won’t work because.” Ideas don’t survive on their own; they survive because a few people gave them oxygen at the moment they were most fragile.”
