We work on minimal residual disease and metastasis by colorectal cancer from the perspective of cancer stem cells and their interaction with the tumor microenvironment.
@IRBBarcelona,bsky.social
The Batlle Lab
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🙏Thank you to Ràdio Barcelona for the Toresky Award 🎙️
🏆Although it recognizes a “personality,” the lab’s discoveries are the result of my team’s dedication and passion
🥼PhDs, postdocs, & senior members work relentlessly to make possible the breakthroughs being recognized today 🙌
✨Huge thanks to all
The Batlle Lab
Leuven at this time of the year was an extra bonus.
1/17 🧵
🙌Thrilled to share our first hard-core immunology paper out today in Nature Genetics! 👇
➡️We unravel how TGFβ suppresses the innate and adaptive immune system in microsatellite stable colorectal cancer (MSS CRC).
Very proud of the team and efforts behind it.
www.nature.com/articles/s41...
🧵1/17
📣Thrilled to share our latest study just out in Cancer Discovery!
➡️
aacrjournals.org/cancerdiscov...
Our recent Cancer Discovery study (Centonze et al.) shows that within hours, metastatic CRC cells switch from an EMP1⁺ invasive state to an LGR5⁺ stem-like program, highlighting that Plasticity is a dynamic, regulated cell-state decision
#Bluetorial below👇🏼
#KRAS #Plasticity #ColorectalCancer
At the Tumor Heterogeneity, Plasticity & Therapy conference in Leuven! 🌟🇧🇪 Huge thanks to the organizers for the invitation. 🙌
Tumour heterogeneity and plasticity are critical areas that are reshaping how we understand therapy resistance and tumour evolution.🔬
www.vibconferences.be/events/tumor...
The Batlle Lab
Yesterday in Valencia Dr. @nlbigas.bsky.social received the 2025 Premio Rei Jaume I in Biomedical Research. Her work on how cancer mutations arise and evolve has earned major recognition!
Congratulations, Núria! 🙌
#ReiJaumeI #CancerResearch
@cerca.cat @icreacommunity.bsky.social @bbglab.bsky.social
Abstract. Inhibitors of the oncogene KRAS hold promise for treating metastatic CRC (mCRC). Here we show that a selective, covalent small molecule inhibitor of the active (ON) conformation of RAS-G12D,...
PODCAST: Conversaciones del Premio Nobel
Producida por Nobel Prize Outreach y la @fundacionareces.bsky.social, los podcast de la serie "Conversaciones del Premio Nobel " proponen acercar a la sociedad española los logros de estos científicos y sus historias personales.
IRB Barcelona
⏳Countdown to the 14th #CNAGSymposium!
🗣️Don’t miss Dr. Eduard Batlle from @irbbarcelona.org (@icreacommunity.bsky.social), sharing his insights on “Plasticity, therapy resistance, and immune evasion in metastatic colorectal cancer”
🗓️Dec 16, BCN
📎 www.cnag.eu/events/14th-...
@batllelab.bsky.social
Video
CNAG
Sociedad Española de Bioquímica y Biología Molecular (SEBBM)
🧵1/17
📣Thrilled to share our latest study just out in Cancer Discovery!
➡️
aacrjournals.org/cancerdiscov...
aacrjournals.org
Abstract. Inhibitors of the oncogene KRAS hold promise for treating metastatic CRC (mCRC). Here we show that a selective, covalent small molecule inhibitor of the active (ON) conformation of RAS-G12D,...
Targeting TGFBR1 in transplantable mouse colorectal tumor organoids improves response to anti-PD-L1 therapy. Mechanistically, TGF-β abrogates clonal expansion of T effector and memory phenotypes and i...
