Phage-encoded small RNA hijacks host replication machinery to support the phage lytic cycle
🚨Happy to share our new mini-review on phage-encoded small RNAs and their potential for phage therapy and antibacterial strategies, written with Aviezer Silverman!
journals.sagepub.com/doi/10.1177/...
#RNA
#phage
@journals.sagepub.com
@hebrewuniversity.bsky.social
@phagedirectory.bsky.social
Phage-encoded small RNA hijacks host replication machinery to support the phage lytic cycle: Molecular Cell www.cell.com/molecular-ce...
Last week we started the day with a lab hike and breakfast in the beautiful mountains around our faculty. Team bonding before getting back to science!
#RNA
@hebrewuniversity.bsky.social
tRNA gene arrays: emerging roles in bacterial persistence and adaptive evolution
Using RIL-seq, Silverman et al. map the RNA interactome of E. coli during phage lambda infection and uncover a conserved phage-encoded sRNA that activates host replication machinery. Their findings reveal a previously unrecognized RNA-level regulatory layer in phage-host interactions and highlight the role of post-transcriptional control in promoting phage infection.
Warm wishes for the new year from the Melamed lab! I am happy to work with such a great team. Wishing you curiosity, progress, and shared success.
Bacteriophages (phages) are viruses that specifically infect bacteria and play a central role in shaping microbial communities and bacterial evolution. Beyond t...
Using RIL-seq, Silverman et al. map the RNA interactome of E. coli during phage lambda
infection and uncover a conserved phage-encoded sRNA that activates host replication
machinery. Their findings re...
Proud to see our work featured in this Spotlight in @cp-trendsmicrobiol.bsky.social by @mvelascogomariz.bsky.social and @jenshoer.bsky.social!
They highlight how phage infection involves surprisingly rich posttranscriptional regulatory networks and sRNA-based regulation.
Thank you for the spotlight!
I never expected horses 🐎 in my RNA research, but here we are 😁
In our new perspective, Simon Dove and I discuss how RIL-seq maps transcriptome-wide sRNA networks in vivo and how iRIL-seq expands the RNA–RNA interaction toolbox.
journals.asm.org/doi/10.1128/...
@hebrewuniversity.bsky.social
Most scientific papers are written for other scientists. We were happy to write for JoLSP, a postdoc initiative, a lay summary of our research on how a tiny viral RNA hijacks bacterial replication machinery.
www.journaloflifesciences.org/archives/157...
#RNA #phages
@hebrewuniversity.bsky.social
Osterman Ilya
Sahar Melamed
Emmanuele Severi
Trends in Microbiology
Sahar Melamed
Diverse genomes of lytic phages are found in bacterial assemblies, challenging assumptions about the nature of the lytic lifestyle.
Bacterial tRNA genes often form arrays that are thought to enhance translational efficiency. Recent work shows that tRNA gene arrays also regulate persistence in Burkholderia, correlating with phylogenetic relationships. These findings implicate tRNA gene arrays in niche-specific adaptive evolution, extending bacterial persistence beyond survival under lethal stresses.
Small RNAs (sRNAs) are bacterial RNA species that are anywhere between 50 and 500
nucleotides in length. Many sRNAs employ a short sequence (as few as 6 nucleotides),
known as the seed sequence, to ba...
Like bacteria, phages use sRNAs to regulate gene expression! Out today in @cp-trendsmicrobiol.bsky.social, @mvelascogomariz.bsky.social and I highlight a recent RIL-seq study from the @saharmelamed.bsky.social lab that looked into posttranscriptional regulation of lambda!
tinyurl.com/lambda-RIL-seq
Jens Hör
Phages employ sophisticated transcriptional regulatory networks to optimize replication. Recently, Silverman et al. used RIL-seq (RNA interaction by l…
