Hope Funds for Cancer Research Postdoctoral Fellow in the Jaffrey lab at Weill Cornell Medicine, former PhD in the Soller lab, UoB. Interested in RNA-binding proteins and RNA modifications; #RNA #RNAmodifications #Genetics 🧫🪰 #MolecularBiology #Evolution
David McQuarrie
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WTAP tetramer ensures m6A writer assembly and faithful mitosis
link.springer.com/article/10.1...
Capolavoro 🎨 alert 🚨! What is the role of gene body methylation in invertebrates? Despite extensive speculation linking it to plasticity and environmental responses, its mechanistic effects and heritability remain unclear. Our take out in @natecoevo.nature.com: www.nature.com/articles/s41... 1/
1/ A new preprint from my lab is out now: “The E. coli DEAD box ATPase, CsdA, is a NAD+ capped RNA binding protein” lead by my graduate student Kaustuv Das with the assistance of @childerslab-pitt.bsky.social -pitt.bsky.social and @schraderlab.bsky.social
www.biorxiv.org/content/10.6...
New in The Innovation Life!
In this review, Rong et al. use domestic pigs as a model to examine how selection intensity and gene flow shape trait genetic architecture prior to reproductive isolation.
doi.org/10.59717/j.x...
#susscrofa #Evolution #GeneFlow
Understanding biodiversity trends requires long-term monitoring and baseline data. This analysis shows 20th century insect declines in Switzerland & more recent partial recoveries and identifies drivers of both trends.
www.nature.com/articles/s41...
Does your designed active site already exist in nature? Is an uncharacterized protein hiding a catalytic site or a pocket? Folddisco answers both, searching millions of structures for a 3D motif in seconds.
@natbiotech.nature.com 🧬
đź“„ www.nature.com/articles/s41...
🧵1/7👇
New online: Soma-to-germline miRNA inheritance through yolk promotes stress resilience in progeny
Finally out in @Cellcellpress!
Proteins with long IDRs are prone to misfolding during protein synthesis.
This is prevented by mRNA 3′UTRs that act as mRNA-based IDR chaperones.
www.cell.com/cell/fulltex...
11/ We are able to show that CsdA is able to enhance RNA decapping by NudC. Importantly this enhancement in the absence of ATP, suggesting that it is a result of the two proteins interacting, and not CsdA acting as a helicase on the RNA substrate freeing the 5′ end for NudC to act on.
The m6A methyltransferase complex (“writer”) regulates mRNA stability and translation, but how its assembly is orchestrated remains incompletely understood. Wilms’ tumor 1-associating protein (WTAP) i...
Experiments in the cnidarian Nematostella vectensis show a role of gene body methylation in transposable element suppression and that epigenetic inheritance is constrained by chromatin context and tra...
Nature Structural & Molecular Biology, Published online: 22 May 2026; doi:10.1038/s41594-026-01816-5In this study, the authors use the Caenorhabditis elegans model organism to show that maternal microRNAs are delivered from the intestine to embryos by the yolk, where they regulate gene expression and promote stress resilience in offspring.
dlvr.it
www.biorxiv.org
Highly conserved mRNA 3′ UTRs act as co-translational chaperones for intrinsically
disordered regions (IDRs), preventing inter-domain misfolding and enabling biogenesis
of fully active proteins.
NSUN2 is an enzyme that adds a small chemical mark to RNA molecules and uniquely selects its targets based on specific sequence patterns and structural features.
Assessing the magnitude and drivers of recent biodiversity losses requires informative, long-term baseline data. Here the authors reconstruct the temporal trajectories of butterflies and saproxylic be...
