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SFB1361 "Regulation of DNA Repair and Genome Stability" Imprint: https://sfb1361.de/imprint

SFB1361

New publication!!📑 Congrats to the Carell lab on their new paper: "One-Step and universal Strategy for the Synthesis of Hypermodified Uracil Phosphoramidites acp3U and cmnm5U" 🔎Read more here: chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...

📃Just published: New #SFB1361 article by the Krämer lab! "Dual inhibition of PP2A and WEE1 induces apoptosis and mitotic catastrophe in cancer cells" 🔎Read the full paper here: www.sciencedirect.com/science/arti...

Publication alert!!📑 Congrats to the @dikiclab.bsky.social and Beli labs on their joint #SFB1361 publication, covering how DNA-protein cross-links promote cGAS-STING-driven premature aging and embryonic lethality. 🔎Read the paper here: www.science.org/doi/10.1126/...

Publication alert!!📃 Congrats to the Carell lab on their latest work! The article focuses on structural and biochemical characterization of yeast Tcd enzymes installing the post-transcriptional modification ct6A in tRNA. Find out more here: academic.oup.com/nar/article/...

New publication!📃 Happy to share the new joint publication by our #SFB1361 PI's Julian Stingele (@jstingele.bsky.social) and Petra Beli, covering how RNF25 confers mRNA damage tolerance by curbing activation of the integrated stress response. Read more here: www.sciencedirect.com/science/arti...

New publication!!📑 Congrats to the Hofmann lab on their new article exploring how Th17 cells require the DNA repair sensor xeroderma pigmentosum complementation Group C to control oxidative DNA damage in a murine model. 🔎Read more here: www.nature.com/articles/s41...

Publication alert!! 📃 Congratulations to the Hopfner lab (@hopfnerlab.bsky.social) on their new publication: "Recognition and remodelling of nucleosomes and hexasomes by the human INO80 complex" 🔎Find out more here: doi.org/10.1093/nar/...

Huge thanks to everyone who joined our IMB & SFB 1361 conference in Mainz!🎊 “The Evil Within: Regulation and Repair of Endogenous DNA Damage” explored how cells detect, respond to & repair internal genetic threats.🧬 It was great seeing you all! @imbmainz.bsky.social #ISC26DNArepair

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It was an absolute delight to attend the DNA damage and repair meeting at the SFB 1361 Conference. Our students showcased their poster presentation and were thrilled to receive the prestigious best poster prize. Congratulations to all of them! 🎉 @imbmainz.bsky.social

IMB & SFB 1361 Conference 2026 taking place right now 🧬 #ISC26DNArepair

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SFB1361

Institute of Molecular Biology (IMB)

Cardoso lab

The serine/threonine phosphatase-2 (PP2A) controls mitogen-associated signaling and DNA replication. The WEE1 protein tyrosine kinase controls S phase…

www.sciencedirect.com

Dual inhibition of PP2A and WEE1 induces apoptosis and mitotic catastrophe in cancer cells

Abstract. Post-transcriptional modifications near the anticodon of transfer ribonucleic acids (tRNAs) ensure translation fidelity and accuracy. For instanc

academic.oup.com

Structural and biochemical characterization of yeast Tcd enzymes installing the post-transcriptional modification ct6A in tRNA

Excessive RNA damage activates cellular stress responses, triggering cell death. However, pathways that negatively regulate RNA damage responses are l…

www.sciencedirect.com

RNF25 confers mRNA damage tolerance by curbing activation of the integrated stress response

We are excited to share our latest cryo-EM study of the human INO80 remodeler, now featured as a Breakthrough article in NAR @narjournal.bsky.social Check it out here and a big shoutout to @priyanka-pdm.bsky.social and Manmohan et al. for their contributions! 🧬

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Hopfner Lab

⭐NAR Breakthrough! ⭐ 🧬 New #cryo-EM work shows the #humanINO80 motor adapts to DNA unwrapping and can remodel altered particles like #hexasomes - highlighting its versatility across #nucleosome states. 🔬✨ @lmu.de @genecenter-lmu.bsky.social Read the full article here: doi.org/10.1093/nar/...

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Nucleic Acids Research