Behavioral neuroscientist (motivation, inhibitory control, individual variability)
--> flagellab.com
Professor of #Neuroscience & #Psychiatry, University of Michigan #GoBlue
Here for science, community, & to promote things I care about.
Shelly Flagel
Our article examining the effects of chronic #GLP-1 receptor agonist (#semaglutide #ozempic) treatment on the incentive motivational value of a small #food reward and the cue that predicts it is now out in Psychopharmacology.
Open access article 👇
link.springer.com/10.1007/s002...
Shelly Flagel
This marks an important first step toward understanding the psychological and neurobiological impacts of chronic GLP-1 receptor agonist treatment. We have a lot more work to do! 4/
In this case, I think the difference is our treatment paradigm. We are using a chronic GLP-1 receptor agonist treatment regimen (similar to that humans experience), whereas most of what we know from the preclinical literature to-date is based on acute treatment.
I was excited to get into the lab today to help out with an experiment...until I realized I now need readers to make out the labels on eppendorfs and pipettes. #oldPIproblems 🔬🧪🔎
Grateful for the outstanding efforts of THE TEAM, led by Steve Chang, and generous support from the University of Michigan Research Scouts Program (OORRS033123) and NIH (T32DA060142: Christopher Turner, T32DA007281: Daniela Pereira, R25GM086262: Natalia Morales Pagán).
We set out to explore how GLP-1 receptor agonists influence incentive motivational processes. Surprisingly, chronic semaglutide treatment increased motivation for food and associated cues under restricted access, but decreased overall consumption when food was freely available. 2/
While these findings may at first seem counterintuitive compared to reports from human subjects, they suggest that these drugs amplify the reinforcing effects of small rewards and associated cues, leading to quicker satiety. 3/
Excited to share our new GLP-1 receptor agonist study! Chronic semaglutide potentiates motivation for small food rewards and associated cues, but reduces intake when food is freely available—surprising twist! #GLP-1, #behavior #neuroscience #pharmacology 1/
🔗 www.biorxiv.org/cgi/content/...
Shelly Flagel
If you didn’t get a chance to purchase the exclusive 5-year #BlackInNeuro pin last night, I have more with me today! ✨
We’re asking for $15 donations to support BIN programming ❤️ blackinneuro.com/donate
Allies are welcome to purchase pins as well 🙌🏾 #SfN25
Shelly Flagel
Shelly Flagel
Shelly Flagel
Shelly Flagel
Call for papers for a Special Issue on Big Data, AI and Machine Learning in Addiction research, guest edited by @flagel-lab.bsky.social and @gavanm.bsky.social in @psychopharmacology.bsky.social link.springer.com/collections/...
Shelly Flagel
Shelly Flagel
Excited to share our new GLP-1 receptor agonist study! Chronic semaglutide potentiates motivation for small food rewards and associated cues, but reduces intake when food is freely available—surprising twist! #GLP-1, #behavior #neuroscience #pharmacology 1/
🔗 www.biorxiv.org/cgi/content/...
