Our new paper is out! Tracking the stability of DNA origami in-vivo is typically done with fluorescence, but are they still attached to intact DNA nanostructures? Here we introduce PLASTIQ, a method to quantify the structure of DNA nanostructures using tiny blood samples, ligations and PCRs!
Björn Högberg
Nature Nanotechnology, Published online: 16 January 2026; doi:10.1038/s41565-025-02091-zA label-free, DNA-based proximity ligation assay that uses ligatable staple pairs enables the longitudinal quantification of DNA origami structural stability dynamics in vivo, with single-helix resolution for both wireframe and lattice designs.
