Professor of Mol & Dev Bio @ Linköping University 🇮🇹🇸🇪
Group Leader at the Wallenberg Center For Molecular Medicine & SciLifeLab
https://liu.se/en/research/cantu-lab
Curious about how the genome responds to #WNT, but frankly passionate about all Science.
Claudio Cantù
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W Tamina also @annanordin.bsky.social Jente Zijlstra and @ppagella86.bsky.social
We are the Cantù Lab @liu.se
Thanks to
@vetenskapsradet.bsky.social
@Cancerfonden
@scilifelab.se
@kawresearch.bsky.social
@additional ventures
BOCA sites are transcriptional enhancers that are dependent on beta-catenin for priming
We push forward a provocative idea:
To pioneer the chr you do not need to be a DNA-binding protein
What matters is that you carry a DNA-recognition friend (a protein partner can do) and chromatin remodelers
Instead of one protein with domains, beta-catenin pioneers orchestrating a complex of prots
How does beta-catenin do this?
The mechanisms entails chromatin remodelers CBP and HDAC1 (both!) for enhancer opening
The surprise of the surprises was that BOCA sites defy the central tenet of the #WNT field:
TCF/LEF do not occupy these loci in WNT-OFF 😱
BOCA sites need beta-catenin. All of them. Full stop.
Some closed genomic regions open with #WNT signals
They do not of beta-catenin is not around
Tamina defined them BOCA (Bca-dep Opening of Chromatin by Atac)
FASTEN YOUR SEATBELTS:
Tamina Weiss, inspired by previous data from @ppagella86.bsky.social
found that beta-catenin is more than an adaptor protein downstream of #WNT
It is an orchestrator that scouts and opens enhancers for transcriptional activation
@biorxivpreprint.bsky.social
Remarkable CUT& adaptation that maps binding and performs IP to find protein partners? At the same time?
My future Methods sections just got more interesting! (I hope, haha!)
Excellent work by Dr. Nordin! @annanordin.bsky.social
