The Gersch Group developed a well characterized matched chemical pair of inhibitor and degrader for the investigation of the DUB USP7 in #solidcancers together with the Cancer Center at the University Hospital Essen. Congrats to @nikolasklink.bsky.social et al.
www.nature.com/articles/s41...
DUBs regulate key cellular processes, but selective tools are scarce. Here, the authors developed PROTACs for the DUB USP7, comparing degraders with inhibitors. The study provides a valuable toolbox f...
