Finished a run at Ascension 10!
Had to retry the 2nd Act 3 boss (the Queen) several times, but I was sure I could do it with a bit of luck, and I got there in the end.
Deck was primarily a Draw/Discard + Sly strategy, with a bunch of good powers to help (2x Speedster + Envenom + Outbreak)
Princess ChooChoo
Got to A10 with the Silent!
She has some really busted cards in StS2, Accelerant turns a slow poison build into turbo aggro, and Master Planner just gives absurd value after a bit of setup, just keep playing Prepared and getting free stuff...