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TCF1 is a master regulator of T cell stemness – but can it make exhausted cells go backwards? We setup a CRISPR KI system to ask this question, and the answer was unexpected. www.nature.com/articles/s41...
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Exhaustion is a functional state that hampers anti-cancer and antiviral CD8 T cell activity, and is preceded by a stem-like state, maintained by the transcription factor TCF1. Here authors develop mou...
High efficiency CRISPR knock-in demonstrates that TCF1 is insufficient to reverse T cell exhaustion - Nature Communications
www.nature.com
Ian Parish