Thanks for highlighting our work with the other outstanding recent discoveries
Sing Sing Way
Back story (link.growkudos.com/1pt9jbrx24g) behind our recent publication... Maternal Krüppel-like factor 2 (KLF2)+ CD4 T cells promote fertility and fetal tolerance | PNAS www.pnas.org/doi/10.1073/...
Candidalysin promotes fungal-specific Th17 CD4 T cell differentiation and protective systemic immunogenicity - Mucosal Immunology www.mucosalimmunology.org/article/S193...
I keep learning new ways maternal antibodies protect infants! The latest from @babiesresearch.bsky.social on protection against E. coli sepsis and new potential vaccine targets.
Learning immunology from mothers and babies www.sciencedirect.com/science/arti... The maternal-fetal dyad can reveal strategies for improving pregnancy outcomes, but also how immunology works applicable to many other physiological contexts @mucosalimmunol.bsky.social @societymucosalimm.bsky.social
Candidalysin promotes fungal-specific Th17 CD4 T cell differentiation and protective systemic immunogenicity - Mucosal Immunology www.mucosalimmunology.org/article/S193... part of the lab investigates commensal fungi as another example of expanded tolerance, but have instead found immunogenicity
Mama's T cells also need KLF2 for promoting fertility and optimal pregnancy outcomes.
Maternal Krüppel-like factor 2 (KLF2)+ CD4 T cells promote fertility and fetal tolerance | PNAS www.pnas.org/doi/10.1073/...
@Model.ShareSubject www.marchofdimes.org/our-work/res... Our pilot data giving women at high risk for pregnancy complications free mouthwash shows some amazing protective effects! Thank you @marchofdimes.org @proctorgamble.bsky.social
Learning immunology from mothers and babies from @babiesresearch.bsky.social: www.mucosalimmunology.org/article/S193...
Protective maternal gut instincts www.nature.com/articles/d41...
So thankful to @nature.com for the opportunity to highlight another exciting example of immunology learned from mothers, “protective maternal gut instincts” by @aiinglim.bsky.social @princetonmolbio.bsky.social
Sing Sing Way
Pregnancy is an immunological marvel allowing intimate approximation between genetically discordant tissues of maternal and fetal origin. Shared immun…
Pregnancy is remarkable in that mothers tolerate the developing fetus expressing immunologically foreign paternal antigens. These foreign antigens stimulate rejection in other contexts, such as organ ...
Pregnancy poses many challenges, including protecting against infection and increased nutritional demands. Pregnancy-associated gut changes offer some help.
Another twist to why newborn babies more vulnerable to infection. Beyond immune cell immaturity, layering, active suppression... maternal pathogen-targeted antibodies still protect. Grateful @Nature sharing this hopefully uplifting glass half (99.9%)-full perspective www.nature.com/articles/s41...
Sing Sing Way
In our latest episode, we discuss new work from the lab of Dr. Sing Sing Way at Cincinnati Children’s Hospital.
It shows that newborns with E. coli #sepsis lack protective maternal antibodies, and maternal priming can provide protection.
1️⃣ https://go.nature.com/40rtn2U
2️⃣ https://bit.ly/4sYIflI
www.nature.com
Neonatal sepsis caused by Escherichia coli is associated with reduced transfer of pathogen-specific maternal antibodies and, in a mouse model, can be prevented by maternal preconceptual ...
