New online! Overcoming conformational strain in directed C3-C(sp3)–H activation for saturated azacycles: Nature Catalysis, Published online: 09 June 2026; doi:10.1038/s41929-026-01549-0Functionalization of saturated azacycles through Pd-catalysed C3-C(sp3)–H activation leveraging the endocyclic…
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Nature Catalysis, Published online: 09 June 2026; doi:10.1038/s41929-026-01549-0Functionalization of saturated azacycles through Pd-catalysed C3-C(sp3)–H activation leveraging the endocyclic nitrogen as a directing group has been hindered by the intrinsic geometric strain of the palladacycle intermediate. Now, an amine N-oxide strategy overcomes this issue by forming a favourable five-membered palladacycle transition state, enabling selective C3 arylation.
