New online! Conformation-driven C3-C(sp3)–H arylation of saturated azacycles using Pd catalyst: Nature Catalysis, Published online: 02 June 2026; doi:10.1038/s41929-026-01548-1The C–H activation of secondary and tertiary amines under directed Pd(II) catalysis remains challenging. Now the authors…
Nature Catalysis, Published online: 02 June 2026; doi:10.1038/s41929-026-01548-1The C–H activation of secondary and tertiary amines under directed Pd(II) catalysis remains challenging. Now the authors report a Pd-catalysed, site- and diastereoselective C3-C(sp3)–H arylation of saturated azacycles, enabled by conversion of the endocyclic nitrogen as N-oxide directing group and a bifunctional ligand.
