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by @jimpick.com
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Happy to announce publication of a collaboration between my group, Neelam Sen's lab and Alan Hinnebusch at NAR combining FACS-uORF (MPRA) and Ribo-seq to clarify how Ded1 enhances mRNA translation. Great team effort! academic.oup.com/nar/article/...
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Abstract. Ded1 is an essential DEAD-box helicase in yeast that broadly stimulates translation initiation and is critical for messenger RNAs (mRNAs) with st
academic.oup.com
Suppression of upstream ORF translation is not a widespread mechanism of translational stimulation by yeast helicase Ded1
McManus Lab at CMU