Lu et al. profiled >10,000 plasma & CSF samples to uncover how APOE2 & APOE4 confer divergent AD risk. APOE2 protects by sustaining homeostatic & anti-inflammatory signatures before Aβ accumulation, whereas APOE4 proteomic changes respond after pathology www.nature.com/articles/s43...
Apolipoprotein E (APOE) is the strongest genetic influence in Alzheimer’s disease (AD). Compared to the most frequent allele, ε3, the ε4 allele increases AD risk, and the ε2 allele is protective. Here...
