New in Nature: de Faria et al. show focal white matter lesions trigger remote microglial response to demyelinated neurons in grey matter, which is required for remyelination. Deplete grey matter microglia→repair failures→chronic grey matter inflammation
doi.org/10.1038/s415...
A transient grey matter microgliosis is required for remyelination, the failure of which results in a chronic neuroinflammatory state seen in neurodegenerative disorders.
