MAPT p.R406W disrupts autophagy–lysosome pathway, impairing Tau degradation. Mutant neurons accumulate Tau/pTau in lysosomes, impairing motility, autophagosome fusion, & clearance. Autophagy enhancement lowers Tau & restores degradation but doesn't rescue trafficking www.nature.com/articles/s41...
Researchers show that a disease-causing Tau mutation disrupts the autophagy-lysosome pathway in human neurons, leading to Tau accumulation, and that enhancing autophagy can partially restore protein c...
