Lee Armstrong, Yogesh Kulathu @kulathu.bsky.social and co-workers show that MINDY3's EF-hand domain is a novel #ubiquitin binding domain. It not only enables chain-length-dependent deubiquitination but also binds to DNA repair factors RAD23A/B.
-> link.springer.com/article/10.1...
The MINDY family of deubiquitinases (DUBs) are exemplified by their preference for cleaving K48-linked polyubiquitin. MINDY3 is architecturally distinct from other MINDY DUBs as its catalytic domain s...
