Just out: Structural dynamics of the π-stacking network governing cofactor-substrate cooperativity of SbSOMT methyltransferase
Communications Chemistry, Published online: 08 June 2026; doi:10.1038/s42004-026-02087-3SAM-dependent methyltransferases facilitate methyl transfer from cofactors to substrates, yet the structural dynamics influencing cofactor-substrate binding cooperativity remain unclear. Here, the authors reveal that SbSOMT, a plant O-methyltransferase, exhibits bilateral and positive cofactor-substrate cooperativity driven by a dynamic π-stacking network and is sensitive to the cofactor-substrate interaction at the methyl binding site.
