Just out: Digital twin of biomacromolecular thermodynamics in cryo-EM data
Communications Chemistry, Published online: 05 June 2026; doi:10.1038/s42004-026-02077-5Understanding the thermodynamics of biomacromolecules is crucial for elucidating their mechanisms yet remains challenging with current cryo-electron microscopy (cryo-EM) methodology. Here, the authors introduce a deep learning framework that reconstructs a “digital twin" of cryo-EM data, enabling precise thermodynamic analysis using only cryo-EM data and revealing insights into biomolecular dynamics without supplementary assumption.
