Just out: One pot sulfur(IV) fluoride-mediated deoxyaminations for the syntheses of 3,3-arylamino oxetanes and azetidines
Communications Chemistry, Published online: 29 May 2026; doi:10.1038/s42004-026-02061-zFunctionalized oxetanes and azetidines hold potential as bioisosteres, but their use in agrochemical and pharmaceutical screenings is hindered by synthetic challenges. Here, the authors employ XtalFluor-E® for a mild one-step deoxyamination, achieving 30–97% yields in one hour or less, and provide mechanistic insights through multivariate linear regression and density functional theory, enhancing their synthetic accessibility.
