Personal account of the Director of Research at Cure Parkinson's - All views my own - Kiwi - Kia kaha - 侘寂 - https://scienceofparkinsons.com/
The Science of Parkinson's
AC Immune announces that they have received a research grant from Goradia Family to support extending Part 1 of the ongoing Phase 2 VacSYn trial of ACI-7104, an active anti-alpha-synuclein immunotherapy (vaccine), in early #Parkinsons
ir.acimmune.com/news-release...
Is #Parkinsons simply "one phenotypic expression of brain aging rather than a discrete disease entity"? & could this reconceptualization "improve biomarker development, clinical trial design, & patient communication"?
www.prd-journal.com/article/S135...
New research proposes stimulator of interferon genes (STING) & the unfolded protein response (UPR) as key immune regulators targetable for therapeutic intervention during autoimmune diseases & #Parkinsons
www.cell.com/cell-reports...
Post-mortem brain tissue analysis of the cingulate gyrus & inferior temporal gyrus, obtained from 20 dementia with Lewy bodies & 20 control cases, do not find an association between lewy body density & neuronal or synaptic loss in DLB
onlinelibrary.wiley.com/doi/10.1111/...
Interesting: Biogen researchers publish preclinical data (mice & NHPs) evaluating intracisterna magna & intraparenchymal administration of a AAV9-GBA1 gene therapy approach for #Parkinsons, which concludes "further technological advances are needed"
www.cell.com/molecular-th...
Very pretty: Researchers introduce a streamline-wise framework to map axonal degeneration & derive disease-specific fiber “degeneromes” across #Alzheimers, #Parkinsons, multiple system atrophy (MSA), & progressive supranuclear palsy (PSP)
www.nature.com/articles/s41...
New research explores the feasibility, reliability, & validity findings of a remote, self-administered, smartphone cognitive testing in a registry-based cohort (N = 1815; ages 18–92)
alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
There are lots of overlaps between #Alzheimers & #Parkinsons. A new mini-review explores convergent proteinopathies & mitochondrial dysfunction across the conditions
www.frontiersin.org/journals/neu...
Using multiple in vitro & in vivo models of #Parkinsons, researchers report that N-terminal acetylation slowed aggregation of both α-synuclein monomers & pre-formed fibrils; Could this post-translational modification represents a protective mechanism
www.sciencedirect.com/science/arti...
The boundary between aging and neurodegenerative disorders remains unresolved, and
emerging evidence challenges this dichotomy. Parkinson's disease (PD) has traditionally
been defined as a neurodegene...
