Happy to share our review of seipin as a lipid rheostat, not just a #lipiddroplet biogenesis factor. Its flexible structure, with cofactors and ligands, integrates metabolic cues at organelle contacts, coordinating lipid storage, membrane synthesis, and signaling.
rupress.org/jcb/article/...
Thiam and Carpentier review seipin as a conformationally dynamic lipid rheostat that steers lipid fate and preserves cellular metabolic balance.
