1/5
Cell identity is written in the proteome, not in the DNA, and not always in the RNA. Out on bioRxiv today: The first cell type-resolved, MS-based proteomic atlas of the human body.
www.biorxiv.org/content/10.6...
Our @MichaelJFoxOrg #ASAP grant brings the Mann lab's spatial proteomics — at single-cell-type resolution — to Parkinson's, the world's fastest-growing neurological disease. With Laura Parkkinen (Oxford University), Günter Höglinger & Franziska Hopfner (LMU Klinikum). #Proteomics
4/5
Cell type resolution exposes biology bulk profiling misses. We find cancer-testis antigens, proteins normally restricted to immune-privileged sites and actively targeted by immunotherapies, in oocytes of the female germline. Worth noting for CTA-directed therapy safety.
2/5
27 cell types × 14 tissues × ~14,000 proteins measured directly in tissue by Deep Visual Proteomics. The human proteome partitions into two regimes: A universal core that sustains cellular life, and tightly restricted programs that define cell type identity. Surprisingly little in between.