Congratulations to the Bach group (@bach-lab.bsky.social) for this very nice Co-catalyzed asymmetric C-H alkylation, to which we contributed a few DFT calculations: pubs.acs.org/doi/10.1021/...
Upon catalysis (1 mol %) by a chiral cobalt porphyrin, quinazolinones with a tethered diazo alkane precursor underwent an enantioselective C–H alkylation at carbon atom C4. Formation of five-, six-, a...
