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Exploring the molecular biology of #ubiquitin and #VCPp97 -mediated stress responses in cells, #proteostasis, #lysophagy, #autophagy, #DNArepair. http://udue.de/qmTDR
Hemmo Meyer Lab
Meeting new and old friends at the JPS conference in Kyoto, Japan. Presented our newest data on the #Lysosome Damage Response. #ATXN3 Thanks to the organizers.
7mo
Thrilled to be hosting Brenda Schulman, @aakritijain.bsky.social, @crismayorruiz.bsky.social @davidbalchin.bsky.social, @hemmo-lab.bsky.social, Ian Ganley, @kirsteinlab.bsky.social, Juliette Fedry, @elliottlab.bsky.social & @plantophagy.bsky.social - BIG THANKS for accepting the invitation πŸ™
Excellent talk by our @unidue-zmb.bsky.social colleague Pinki Galhot from @hemmo-lab.bsky.social @imprs-lm.bsky.social πŸ‘ #MK2026 @gbmev.bsky.social
Hemmo Meyer Lab
5mo
2mo
Great #ubfriends2026 meeting in Vienna. Presented our data on FAF1/2 mediated substrate loading onto VCP/p97. Fantastic talks, discussions and hospitality. Big thank you to the organizers! #ubiquitin
Finally celebrating Matthiβ€˜s paper publication on p97β€˜s accessory adapters. Great job. doi.org/10.1126/scia...
Cdc48/p97 nibbling on #ubiquitin! Cool single molecule analysis study by the Tans group (with us) out now. rdcu.be/firGK
The Meyer lab Xmas dinner once again with traditional German skittle competition. We won! 🎳
VCP/p97’s accessory adapters (FAF1, FAF2, UBXN7) boost unfolding and subsequent proteasomal degradation. #ubiquitin. Our paper is out now: Science Advances www.science.org/doi/10.1126/...
Fantastic and productive meeting with the labs of Tamotsu Yoshimori, Shuhei Nakamura, Akiko Kuma at #Osaka University. Discussing perspectives of #microautophagy in th #lysosome regeneration after damage. Thanks so much for hosting me.
Fantastic #autophagy meeting on the Oslo Fjord. Great talks and plenty of time and activities for discussion. Thanks to Anne, Ivan, Sharon and the other organizers for a great event.
1mo
2mo
1mo
6mo
3mo
7mo
17d
SFB Targeted Protein Degradation
Hellerschmied Lab
Hemmo Meyer Lab
Hemmo Meyer Lab
Hemmo Meyer Lab
Hemmo Meyer Lab
Hemmo Meyer Lab
Hemmo Meyer Lab
Hemmo Meyer Lab
A group of accessory adapters positions the p97 adapter Ufd1 to boost substrate unfolding and subsequent proteasomal degradation.
www.science.org
The accessory adapters FAF1, FAF2, and UBXN7 accelerate proteasomal degradation by increasing prior p97-mediated substrate unfolding