Many thanks to Nature Catalysis and to Prof. Zhang and his colleagues for featuring our manuscript in a News & Views article - this is truly appreciated!
@ribbehulab.bsky.social @ucibiosci.bsky.social @natcatal.nature.com
Ribbe Hu Labs
New online! Gating the nitrogenase cofactor
Nature Catalysis, Published online: 26 March 2026; doi:10.1038/s41929-026-01498-8Biological nitrogen fixation is vital for sustainable agriculture, yet nitrogenase engineering is hindered by limited insight into their essential metallocluster cofactor assembly and transfer. Here, by capturing the nitrogenase biosynthetic component NifEN in multiple structural states, a tunnel-and-switch mechanism that coordinates receipt, maturation and delivery of the FeMo-cofactor precursor is revealed.
