Pleased to share the peer-reviewed version of our latest work on resolving the complexities of a-crystallins/sHSP's: www.nature.com/articles/s41...
A timely release of this story... as it is a great setup to the next one, coming soon!!
Here the authors show that mutating αB-crystallin’s NT-IXI motif transforms polydispersed oligomers into ordered fibrils, enabling cryo-EM to provide insights into the principles of high-order assembl...