In case you missed this #JournalClub馃毃
Terrazas&Pe贸n discuss a recurrent CTNNB1 mutation generating public #neoantigens recognized by engineered #TCRTcells, enabling potent antitumour responses across models
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In this Journal Club, Terrazas and Pe贸n discuss a study that identifies a recurrent CTNNB1 mutation that generates shared neoantigens amenable to engineered T cell receptor (TCR)-T cell recognition. The work demonstrates potent antitumour activity across models and highlights the potential of targeting public mutations to broaden TCR-T cell immunotherapy for solid tumours.
