Hot off the press from the RTI: Systemic dual-gene therapy reverses biochemical intoxication in the central metabolic compartment of Bckdha-/- mice
pubmed.ncbi.nlm.nih.gov/42136029/?ut... #RNA #RNATherapeutics
Branched-chain 2-ketoacid dehydrogenase (BCKDH) deficiency (maple syrup urine disease; MSUD) causes lethal encephalopathy by disrupting cerebral metabolism, a process imperfectly reflected by circulating...