PhD student in Cancer Genomics @bbglab.bsky.social @irbbarcelona.org
Ferriol Calvet
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Very excited to share our new paper on the influence of biological sex and smoking in the clonal landscape of normal human bladder, just published in Nature.
A big thank you and congrats to all the authors, specially to @raquelbmi.bsky.social for all the shared efforts in this journey!
⬇️More info⬇️
Scientists have used low-error genome-sequencing methods in normal tissues from large cohorts of individuals to scan for mutations that set the stage for cancer
go.nature.com/42vakWS
New findings from team PROMINENT in @science.org highlights new ways to think about cancer prevention by modulating clonal dynamics and ensuring that dangerous clones never emerge.
Learn more: www.cancergrandchallenges.org/news/competi...
New research from team PROMINENT (@nlbigas.bsky.social), published in @nature.com, uncovers clues why men face a higher risk of bladder cancer and reveals that tobacco smoke acts as a promoter, not an initiator, in bladder cancer development.
Read more: www.cancergrandchallenges.org/news/early-c...
Major new work by the #TransCODE Consortium out today in @nature.com.
Read all about our efforts to shed light onto the forgotten areas of the human proteome. #Microproteins #Peptideins #DarkProteome
This was a huge global collaboration, in part funded via #NIH
www.nature.com/articles/s41...
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📢 Thrilled to share our latest paper, KDM6 Demethylases Contribute to EWSR1::FLI1-Driven Oncogenic Reprogramming in Ewing Sarcoma, from my PhD, is now published in Cancer Research!
Explore our findings🔬🧬: aacrjournals.org/cancerres/ar...
#Epigenetics #Cancer #EwingSarcoma
Huge thanks to the team!
Tumor promotion through the lens of evolution
This review grew out of many long conversations, shared ideas, and lively discussions
It has been a real pleasure to think together with Allan, Paul, Eve, and Abel about how tumours develop and how carcinogens shape cancer risk
rdcu.be/fdC2J
A short thread. For years, I have been surprised by how much confusion our discovery of clones carrying cancer-driver mutations in normal tissues has caused in the cancer community. Typical questions like: (1) if you see these mutations in normal cells, are they really cancer drivers?... [1/4]
🧪 Out in @nature.com: Smoking and biological sex shape healthy bladder tissue evolution, offering clues to #cancer risk.
✍️ #IRBBarcelona & University of Washington
➡️ bit.ly/42wcIN5
📌 DOI: 10.1038/s41586-025-09521-x
#IRBScience #CancerResearch #BladderCancer @bbglab.bsky.social
🧵👇
Meet our exceptional training team for #CancerEpi2026 💫
Field experts will guide you through how to use the best genomics tools and approaches to detect cancer mutations.
🗓️ 16-18 February 2026
Apply by 3 November - bursaries available
📎 bit.ly/41mRDnD
#OncSky #GeneSky #CancerSky 🧪🖥️🧬
Ferriol Calvet
Nature
A large-scale proteomics analysis of the dark proteome by the TransCODE Consortium reveals many translated non-canonical open reading frames to encode microproteins and peptideins.
Nature - This Review revisits tumour initiation and promotion in light of clonal diversity and the presence of cancer driver mutations in normal tissues, aiming to understand mechanisms that enable...
Scientists have used low-error genome-sequencing methods in normal tissues from large cohorts of individuals to scan for mutations that set the stage for cancer.
🚨 New paper alert!
Sex and smoking bias in the selection of somatic mutations in human bladder
www.nature.com/articles/s41...
by @raquelbmi.bsky.social, @ferriol.bsky.social et al (in collaboration with Rosana Risques lab in @uwmedicine.bsky.social)
John Prensner
Bet Figuerola
Nuria Lopez-Bigas
Video
Inigo Martincorena
Abstract. Ewing Sarcoma (EwS) is a highly aggressive tumor arising in bones and soft tissues driven by the fusion oncoprotein EWSR1::FLI1. This aberrant transcription factor binds to GGAA microsatelli...
Sex bias and association with smoking history identified in the landscape of driver mutations and clonal expansions in normal human bladder tissue may explain the higher bladder cancer risk in men and smokers.
Our latest work is out in Nature today. In this paper, we introduce an improved version of NanoSeq, a duplex sequencing protocol with <5 errors per billion bp in single DNA molecules, and use it to study the somatic mutation landscape of oral epithelium in >1000 people www.nature.com/articles/s41...
Inigo Martincorena
A new version of nanorate DNA sequencing, with an error rate lower than five errors per billion base pairs and compatible with whole-exome and targeted capture, enables epidemiological-scale studies of somatic mutation and selection and the generation of high-resolution selection maps across coding and non-coding sites for many genes.
