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The Somatic Cell Genome Editing (SCGE) Consortium is an NIH Common Fund program that aims to develop safe and effective methods to perform gene editing to treat genetic diseases in somatic cells. Reposts/likes do not equal endorsements. scge.mcw.edu
SCGE
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Dr. Pan is a Research Assistant Professor at the University of Florida College of Pharmacy, and is part of the SCGE project titled "Evaluation of High-throughput Extracellular Vesicle Loading Platform for Therapeutic Genome Editing INDs".
In this SCGE "Meet the Researcher" interview, hear from Dr. Xiaoshu Pan as she highlights the benefits of extracellular vesicles (EVs) as a delivery method for gene therapies, and discusses the next milestones in her SCGE project. Watch the interview: www.youtube.com/watch?v=0HTR...
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Collectively, these technologies provide complementary insights across different scales, from the single nucleotide to the whole organism, bridging preclinical therapeutics development with clinical trials. (3/3)
Emerging technologies to monitor the biological effects of genome editors cover a range of biological scales, from the direct measurement of editing outcomes in DNA, to human microphysiological systems, and non-invasive in vivo imaging. (2/3)
In this SCGE researcher interview, Dr. Mei He highlights how her teams' high-throughput extracellular vesicle loading platform improves the delivery of genome editors and discusses the different kinds of expertise needed to build her research project. www.youtube.com/watch?v=cmor...
Dr. He is an Associate Professor at the University of Florida College of Pharmacy, and is the PI on the SCGE project titled "Evaluation of High-throughput Extracellular Vesicle Loading Platform for Therapeutic Genome Editing INDs". scge.mcw.edu/phase-2-tech...
CRISPR-based genome editing therapeutics are entering the clinic, offering transformative potential but also presenting potential risks. Preclinical-to-clinical toolkits are needed to assess the safety and efficacy of these new therapies and accelerate progress. (1/3) www.nature.com/articles/s41...