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Excited to share our new paper, co-led by Gracyn Buenconsejo and me. Why did a promising anti-#Cryptosporidium drug fail? We asked whether the parasite itself might already be genetically prepared to escape treatment. doi.org/10.1038/s415... #Clofazimine #forwardgenetics
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Forward and reverse genetics identifies the mode of action of clofazimine in the parasite Cryptosporidium. The genomic locus encoding the target is heterogeneous, and a resistance-conferring allele is...
doi.org
Genomic heterogeneity of NAD(P)H dehydrogenase predisposes Cryptosporidium to clofazimine resistance - Nature Microbiology
Sebastian Shaw