Submitted an R01 last week on a project my lab's worked on for 4+ yrs, & I've debated proposing for 3+ yrs.
This was my 26th NIH app (as PI, MPI, or Co-I) over 7 yrs (5 ND, 1 ND-C, 18 scored, 7 funded, 2 pndg), and this may be the proposal I'm most proud of going in.
Will it matter? Stay tuned...