Huge congratulations to Dr @danielweiriav.bsky.social, outstanding scientist and wonderful colleague, who passed his viva with flying colours today @cvrinfo.bsky.social. Next stop, on to Oxford for a postdoc with @efodor.bsky.social - we're really excited to see what you do next! 🦠🥳 #PhDone
Decoding influenza virus: From polymerase mechanisms to translational therapeutics
www.sciencedirect.com/science/arti...
Nature research paper: Mechanism of co-transcriptional cap snatching by influenza polymerase
go.nature.com/4rTPL12
How does fever work?
Our new Science paper shows how elevated body temperature can protect against severe influenza and that avian-origin viruses escape this defence.
This is likely one reason why bird flus and some pandemic influenzas can be so severe.🧵
www.science.org/doi/10.1126/...
Cryo-EM structure reveals how influenza A virus NEP binds the viral polymerase at a regulatory hotspot, coordinating RNA synthesis and nuclear export. Fantastic collaboration with @loiccarrique.bsky.social and Jon Grimes. www.science.org/doi/10.1126/...
Big welcome to @corneliusleeyh.bsky.social starting his DPhil with @achilleskap.bsky.social @kavlioxford.bsky.social & @efodor.bsky.social @dunnschool.bsky.social on influenza dynamics! Great to see this cross-disciplinary project getting underway.
Our work on influenza genome packaging using high-throughput single-virion DNA-PAINT is out in NAR! Packaging appears structurally diverse and flexible. Big thanks to Christoff & Qing (amazing effort)! A collab with @efodor.bsky.social, @nicolerobb.bsky.social academic.oup.com/nar/article/...
Our PhD studentship programme is officially open; pass it on
If you are looking for a fully-funded PhD in the mechanisms underlying human disease, here are the details...
Great science and a great environment!
www.path.ox.ac.uk/news-article...
Video
Ervin Fodor
Ed Hutchinson
Host body temperature can define a virus’s replicative profile—influenza A viruses (IAVs) adapted to 40° to 42°C in birds are less temperature sensitive in vitro compared with human isolates adapted t...
Very happy to have been able to contribute to this study that was published today in Science, which was truly a great collaborative effort. Avian PB1 provides a fitness advantage to IAV at febrile-range temperatures both in vitro and a hyperthermic nouse model 🦠www.science.org/doi/10.1126/...
#flu
Transient RNA structures play a key role in the emergence of highly pathogenic avian influenza viruses! Great to see this collaboration with Mathis Funk, Mathilde Richard, Stephen Cusack, and others in @science.org www.science.org/doi/10.1126/...
Ervin Fodor
Structural and biochemical studies of influenza virus RNA-dependent RNA polymerase (FluPol) in complex with transcribing host RNA polymerase II reveal the molecular mechanisms of RNA cap snatching by FluPol.
Abstract. Influenza A, a negative-sense RNA virus, has a genome that consists of eight single-stranded RNA segments. Influenza co-infections can result in
Host body temperature can define a virus’s replicative profile—influenza A viruses (IAVs) adapted to 40° to 42°C in birds are less temperature sensitive in vitro compared with human isolates adapted t...
Highly pathogenic avian influenza viruses (HPAIVs) derive from H5 and H7 low pathogenic avian influenza viruses (LPAIVs). Although insertion of a furin-cleavable multibasic cleavage site (MBCS) in the...
Officially starting my DPhil in Condensed Matter Physics with @achilleskap.bsky.social (@kavlioxford.bsky.social) and @efodor.bsky.social (@dunnschool.bsky.social)! A collaborative project to understand influenza dynamics. Excited to see where this project goes!
